Description

What is Niftran 100mg (Nitrofurantoin)?

Niftran 100mg is an antibacterial medication used to treat urinary tract infections (UTIs) caused by certain bacteria. It belongs to the class of nitrofurans and works by inhibiting the growth of bacteria in the urinary tract. Niftran 100mg is manufactured by the reputable pharmaceutical company, AstraZeneca.

Composition

Niftran 100mg contains the active ingredient Nitrofurantoin, which is available in a strength of 100mg per capsule. The inactive ingredients include:

• Microcrystalline cellulose
• Silica, colloidal anhydrous
• Magnesium stearate
• Talc
• Opadry II White (hypromellose, lactose monohydrate, titanium dioxide, and triacetin)

Uses / Indications

Niftran 100mg is used to treat the following medical conditions:

• Urinary tract infections (UTIs) caused by susceptible bacterial strains, such as Escherichia coli, Staphylococcus saprophyticus, and other Gram-negative bacilli.
• Cystitis (bladder infection)
• Pyelonephritis (kidney infection)
• Acute uncomplicated cystitis or pyelonephritis in women.

How It Works (Mechanism of Action)

Niftran 100mg works by inhibiting the growth of bacteria in the urinary tract. It does this by damaging the bacterial DNA, which prevents the bacteria from reproducing and multiplying. This leads to a reduction in the severity of the infection and helps the body’s natural defense mechanisms to fight off the infection.

Dosage & Administration

The recommended dosage of Niftran 100mg is:

• Adults: 100mg every 12 hours for 7 to 14 days, depending on the severity of the infection.
• Children: The dosage may vary depending on the child’s age and weight. Consult a doctor or pharmacist for guidance.

Niftran 100mg capsules should be taken orally with food to reduce the risk of gastrointestinal side effects. It is essential to drink plenty of water while taking Niftran 100mg to prevent kidney damage.

Side Effects

The common side effects of Niftran 100mg include:

• Diarrhea
• Nausea
• Abdominal pain
• Vomiting
• Headache
• Dizziness

The serious side effects of Niftran 100mg include:

• Severe allergic reactions, such as anaphylaxis
• Severe diarrhea, which may lead to dehydration and electrolyte imbalances
• Severe abdominal pain, which may indicate a more serious condition, such as a bowel obstruction
• Pneumonia or other respiratory infections

Warnings & Precautions

Niftran 100mg may not be suitable for everyone, particularly:

• Pregnant women: Niftran 100mg should only be used if the benefits outweigh the risks. Consult a doctor before taking this medication.
• Breastfeeding mothers: Niftran 100mg may pass into breast milk and affect the baby’s health.
• Elderly patients: Niftran 100mg may increase the risk of respiratory infections and other complications in older adults.
• Patients with kidney or liver disease: Niftran 100mg may worsen kidney or liver function in patients with pre-existing conditions.
• Patients with respiratory disease: Niftran 100mg may worsen respiratory symptoms in patients with conditions such as asthma or chronic obstructive pulmonary disease (COPD).
• Patients who operate heavy machinery or drive: Niftran 100mg may cause dizziness or drowsiness, which can impair driving ability or increase the risk of accidents.
• Patients who consume alcohol: Niftran 100mg may interact with alcohol and increase the risk of adverse effects.

Contraindications

Niftran 100mg should not be taken by:

• Patients with a history of severe allergic reactions to nitrofurantoin
• Patients with severe respiratory disease, such as cystic fibrosis or pulmonary fibrosis
• Patients with severe kidney or liver disease
• Patients with a history of epilepsy or other seizure disorders

Drug Interactions

Niftran 100mg may interact with the following medications:

Medication	Interaction
Warfarin	Increased risk of bleeding
Cyclosporine	Increased risk of nephrotoxicity
Other antibiotics	Increased risk of antibiotic resistance

Missed Dose & Overdose

If you miss a dose of Niftran 100mg, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

In case of overdose, seek medical attention immediately. Symptoms of overdose may include:

• Severe vomiting
• Diarrhea
• Abdominal pain
• Nausea
• Headache
• Dizziness

Activated charcoal may be administered to help absorb the medication and reduce the risk of adverse effects.

Storage Instructions

Niftran 100mg capsules should be stored:

• In a tightly closed container to protect from moisture.

• In a cool, dry place, away from direct sunlight and heat sources.

• Out of reach of children and pets.

• At a temperature not exceeding 30°C (86°F).

Conclusion

Niftran 100mg is an effective antibacterial medication used to treat urinary tract infections. However, it is essential to take it as directed and to be aware of the potential side effects and interactions. If you have any questions or concerns, consult a doctor or pharmacist before taking Niftran 100mg.

Frequently Asked Questions (FAQs)

Q1: Can I take Niftran 100mg if I am pregnant?

A: Niftran 100mg should only be used during pregnancy if the benefits outweigh the risks. Consult a doctor before taking this medication.

Q2: Can I take Niftran 100mg if I am breastfeeding?

A: Niftran 100mg may pass into breast milk and affect the baby’s health. Consult a doctor before taking this medication.

Q3: Can I take Niftran 100mg with other medications?

A: Niftran 100mg may interact with other medications, such as warfarin, cyclosporine, and other antibiotics. Consult a doctor or pharmacist before taking this medication with other medications.

Q4: What should I do if I miss a dose of Niftran 100mg?

A: Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule.

Q5: Can I take Niftran 100mg if I have kidney or liver disease?

A: Niftran 100mg may worsen kidney or liver function in patients with pre-existing conditions. Consult a doctor before taking this medication if you have kidney or liver disease.